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KMID : 0369819930230020081
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Jorunal of Korean Pharmaceutical Sciences
1993 Volume.23 No. 2 p.81 ~ p.87
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Study on Polymorphism of Cimetidine
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손영택/Sohn YT
김기수/Kim KS
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Abstract
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Five crystalline forms of cimetidine, four anhydrous and a monohydrate, have been prepared, and their thermal behavriours have been studied by differential thermal analysis and thermo-gravimetry. The dissolution rates of the five forms were determined in distilled water at 37?C. The results showed a significant difference in the dissolution rate. Polymorphic transformation occurred spontaneously during storage at room condition and was accelerated by applied energy during formulation process-milling.
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KEYWORD
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Cimetidine, Thermal analysis, Dissolution rates, Polymorphism, Compression, Milling
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